In-form Tottenham relishing chase of Chelsea

first_imgTottenham Hotspur have the chance to exert psychological pressure on Premier League leaders Chelsea when they open the weekend programme at home to Watford on Saturday.An 11th consecutive home league victory in the lunchtime kick-off (2.30pm) would cut Chelsea’s lead to four points before Antonio Conte’s side play away at Bournemouth in the day’s late game (7.30pm).It seemed Mauricio Pochettino’s Tottenham side had blown any chance of reeling in Chelsea when they trailed Swansea City 1-0 in the 88th minute on Wednesday. But an extraordinary late burst earned them a 3-1 win that kept Chelsea in their sights.Their fifth consecutive victory maintained the seven-point gap and means Pochettino’s side have amassed 29 points since the turn of the year – more than any other side.While Chelsea’s gritty 2-1 victory over Manchester City means it appears to be their title to lose, Tottenham are clearly revelling in the chase, as they did last season in an ultimately futile pursuit of Leicester City.“I believe that we can win every game if we play like we did against Swansea – and then we’ll see,” said Pochettino, whose side host Bournemouth the following week.“We’re still pushing, believing, pressuring Chelsea. It’s important we are showing we learnt from last season.”Conte is well aware of the threat posed by Tottenham and believes six wins from their final eight games could be required to keep Pochettino’s in-form side at bay.Bournemouth, who notched an impressive 2-2 draw at third-placed Liverpool on Wednesday, are a tricky obstacle for Chelsea, who a week later travel to Manchester United.City’s defeat at Stamford Bridge meant Pep Guardiola’s side have gone four games without a win in the league, and a top-four finish is not a formality in the Spaniard’s first season.They host Hull City on Saturday (5pm), needing a victory to maintain their four-point gap over Arsenal and Manchester United, who are fifth and sixth respectively.Third-placed Liverpool are also looking over their shoulder as they prepare to travel to Stoke City (5pm). They are two points above City and six ahead of Arsenal and United, although they have played more games than their rivals.Arsenal, bidding for a 21st consecutive top-four finish, are at Crystal Palace on Monday (10pm) while United, with three draws in their last four games, face bottom club Sunderland on Sunday (3.30pm).While Sunderland look doomed to the drop and 19th-placed Middlesbrough, who host Burnley (Saturday 5pm), are favourites to join them, at least four other clubs are still sweating on survival.One of them, West Ham, have lost five games in a row and their clash with third-from-bottom Swansea (5pm) has all the ingredients of the trademark ‘six-pointer’.Defeat for West Ham, who are five points above 18th-placed Swansea, would leave them firmly in the mire.“One win will change everything,” West Ham manager Slaven Bilic said after Wednesday’s 3-0 loss at Arsenal.“Three points at this stage would be massive.”last_img read more

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‘Sparkplug’ Verano proves worth in Ateneo win over NU

first_imgBREAKING: Solicitor General asks SC to forfeit ABS CBN’s franchise Taiwan minister boards cruise ship turned away by Japan PLAY LIST 01:31Taiwan minister boards cruise ship turned away by Japan01:33WHO: ‘Global stocks of masks and respirators are now insufficient’01:01WHO: now 31,211 virus cases in China 102:02Vitamin C prevents but doesn’t cure diseases like coronavirus—medic03:07’HINDI PANG-SPORTS LANG!’03:03SILIP SA INTEL FUND BREAKING: Solicitor General asks SC to forfeit ABS CBN’s franchise For the complete collegiate sports coverage including scores, schedules and stories, visit Inquirer Varsity. Mainland China virus cases exceed 40,000; deaths rise to 908 View comments Verano came off the bench and provided the spark for the Blue Eagles, pouring 11 of his 20 points in the second quarter to allow his side to take a 34-16 halftime lead. He also got two rebounds and two steals to carry the Eagles to a 6-4 slate, good for solo third.Ateneo coach Sandy Arespacochaga said Verano’s great showing was a longtime coming for him, given the effort he has been putting so far this season.FEATURED STORIESSPORTSGinebra teammates show love for SlaughterSPORTSWe are youngSPORTSCone plans to speak with Slaughter, agent“We’ve seen glimpses of Raffy in some of the other games,” he said. “He’s a sparkplug for us off the bench. He plays well defensively, but he also proved today that he can also score.”As easy as he made things look on Sunday, Verano’s transition to the Philippines wasn’t that simple. Team ‘Trabaho’ scores championship title at the last leg of Smart Siklab Saya Manila PSL-F2 stint in FIVB WCWC an ‘eye-opener’ for PH, says Daquis Ginebra teammates show love for Slaughter MOST READ Raffy Verano. Tristan Tamayo/INQUIRER.netHere’s a name that should ring a bell from now on: Raffy Verano.The Fil-American rookie finally had his breakout game, lifting Ateneo past National University, 65-50 on Sunday.ADVERTISEMENT Sports Related Videospowered by AdSparcRead Next Brad Pitt wins his first acting Oscar as awards get underway “It’s very different. Coming out here, the pace is faster. Usually, I play big here, but I play guard in the States,” the 18-year-old Verano said. “Coming down here, playing the three and the four, it’s starting to get more comfortable. It was a tough transition, but I’m getting used to it.”The victory over the Bulldogs, though, should be the start of greater things for Verano, as he hopes to contribute further to the Blue Eagles’ campaign this season.“It’s going great. I’m really enjoying it here especially in Ateneo with our coaches, team, and school in general. I’m getting more comfortable,” he said.“I just want to help in way possible. If it’s to do the dirty work, to rebound, or just the little things, I’m willing to do anything to help the team out.”ADVERTISEMENT Don’t miss out on the latest news and information. We are young 30 Filipinos from Wuhan quarantined in Capas Chinese-manned vessel unsettles Bohol town Smart hosts first 5G-powered esports exhibition match in PH EDITORS’ PICKlast_img read more

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Tobacco company calls for executive intervention

first_img– says Guyana’s bill more oppressive than Caribbean peersDemerara Tobacco Company Limited (DEMTOCO) has taken its advocacy to the highest office of the land, calling onPresident David Grangerto step in and forestall making the Tobacco Control Bill a law unless certain provisions in the Bill are changed.In a statement released on Tuesday, the company noted that the Government used the passage of the Bill in other countries as justification for the new bill in Guyana. But DEMTOCO said the countries that were cited have actually implemented less stringent laws than the ones passed in the National Assembly last month.Managing Director of DEMTOCO, Maurlain KritonThe company pointed out that both Trinidad and Jamaica have no provisions in their bills which designate a person’s private home as a work place under any circumstances. In addition, the company emphasised that both countries included provisions in their bills to allow outdoor designated smoking areas.“Both Jamaica and Trinidad removed the provision from their Bills, which included a person’s private home as a work place if that owner were to employ a gardener, a helper or some other help around their home,” the company stated. “Those countries viewed the guaranteeing of the right of the privacy of one’s home as a fundamental principle.”DEMTOCO pointed out that neither country sought to bar previous employees in the tobacco industry from working with Government. Noting that the Bill will impact on retailers of a legal product, the company said that the Government can regulate the industry in a more reasonable manner.The company therefore echoed the calls of the Private Sector and other stakeholders that the Bill be sent to a committee. In addition, it called on the President to intervene and have any excessive measures removed as well as to have the Bill sent to a committee.Trinidad banned public smoking in 2010, while Jamaica followed suit three years later. In Guyana, while the need for the Bill was supported by most, several of its clauses have been deemed excessive.Within days of its passage, the Private Sector Commission (PSC) had come out urging Government to consider the civil rights aspect of the Bill. The Commission had stressed that the bill be referred to the Special Select Committee.“Guyana has, over many years, come a long way in controlling the practice of smoking in public places and the public as well as various operators of bars, hotels, cinemas, other businesses and smokers themselves should be applauded,” the commission said.The business association added, “We are aware that the Government of Guyana believes that the World Health Organisation’s Protocols dictate that Government should not engage in dialogue with the tobacco industry. The Private Sector Commission views this as an inconsistency. Ours is an independent jurisdiction called Guyana and most democracies were built on dialogue.”ProvisionsAmong the provisions of the Bill is a ban on smoking in indoor workplaces; public transport, stadiums, parks and national sites. In the Bill, smoking is also prohibited in any area within five metres of a health care, educational or child care facility.Part Five, section 16 (3) states “Any person who smokes in any place where smoking is prohibited commits an offence and is liable on summary conviction to a fine of ten thousand dollars for the first offence, and twenty thousand dollars for any second or subsequent offence.”The Bill provides for a number of other fines and penalties, ranging from $200,000 and six months imprisonment. Corporate bodies can also face fines of up to $9 million for infringing on the ban regarding advertising.The Bill also regulates the sale of cigarettes, as well as prohibits all forms of tobacco advertising, sponsorship and promotion. It also provides for the creation of a National Tobacco Control Council that will provide advice to the Minister of Public Health.last_img read more

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Chelsea fans demand Isco and Rodriguez as reports of secret Madrid talks emerge

first_img1 Eden Hazard of Chelsea Real Madrid are closing in on a deal for Eden Hazard, if reports are to be believed.The LaLiga giants, according to Spanish sources, have been locked in ‘secret talks’ with Chelsea over the past few months over a possible summer transfer.And, understandably, the rumour has alerted some Blues fans.Check out the reaction of a selection of Chelsea supporters below…last_img

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Airlines urge more nations to join carbon offset scheme

first_imgIATA boss Alexandre de Juniac Seventy-two countries representing 80 per cent of international aviation have now signed up to the voluntary phase of a global carbon offset scheme but international airlines want more to join in.A  year after the an historic agreement to establish the Carbon Offsetting and Reduction Scheme for International Aviation (CORSIA), a  call has gone out for greater urgency in the industry’s push to tackle global emissions.The International Air Transport Association wants more help from governments as the  industry moves to tackle climate change.At the top of IATA’s list is broadening the International Civil Aviation Organisation-backed CORSIA scheme.“CORSIA was a historic demonstration of what can be achieved when governments and industry work together,” IATA director general Alexandre de Juniac told a sustainable aviation summit in Geneva this week. “Implementing it will be a critical enabler of aviation’s commitment to carbon neutral growth from 2020.”The world’s first global industry pollution agreement will start as a voluntary scheme from 2021 to 2026 but will then become mandatory across the aviation.Airlines will have to buy carbon credits to offset growth in emissions, a move that is expected to account for less than 2 per cent of revenues but has raised concerns in some states about costs.The scheme will include provisions to deal with special circumstances such as those of fast-growing airlines and airlines which have made significant investments to improve environmental performance already.Some 65 countries signalled a year ago that they would take part in the voluntary phase but only seven have joined since then.Parties that indicated they would  sign up for the voluntary scheme include Singapore, the Uhnited Arab Emirates, the US, European States and some smaller nations. However, Russia and India were among those who have said they will not participate in the first phase.IATA’s de Juniac described the 72 countries participating in the voluntary phase as “an impressive start”.“But CORSIA will be an even bigger success if more countries join in,’’ he said. “Now is the time for the industry, along with those governments already on board, to step up efforts to broaden participation.”The international airline group  says airlines will need to establish systems for monitoring ad verifying carbon out as they prepare for CORSIA.It also warns that governments will need to finalise the technical details of CORSIA early on so that e systems are ready when the scheme is implemented.Other areas IATA wants addressed as it pursues its goal cutting the industry’s net emissions to half their 2005 levels by 2050 include sustainable aviation fuels and improved infrastructure.It wants more government involvement in establishing an aviation biofuels industry that can produce fuel at competitive prices and improvements to infrastructure such as air traffic management.“Air navigation services remain stuck in the architecture of the mid-20th century, while aircraft embrace the technology of the 21st century,’’ de Juniac said. “The political issues which create artificial borders in the sky must be tackled to unlock emissions savings and generate economic opportunities.”last_img read more

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EXCLUSIVE: Emirates’ Sir Tim Clark on the A380, Etihad and his successor

first_imgThe clock is ticking on the latest order for the Airbus A380 but the man at the center of the crucial deal, Emirates president Tim Clark, sees the superjumbo remaining an important part of the airline’s fleet into the 2030s.The Dubai- based carrier’s decision in January to buy a further 20 A380s and take 16 options saved the program from being axed and gave it breathing space.But media reports this week speculated about an impasse or stall of the deal, even a possibility of failure of the whole A380 program survival.Negotiations between Emirates and Rolls-Royce have reportedly stalled on the manufacturer’s inability to meet fuel-improvement guarantees previously given, according to BloombergThe additional aircraft are due to be delivered from 2020, bringing the total A380 orders of the Dubai-based carrier to 178 — it currently flies 106 — and timing is tight.“Propulsion remains an issue, we still haven’t resolved propulsion on the new order yet and haven’t chosen a supplier so far. We are still looking at all of this,” Sir Tim tells  AirlineRatings in an exclusive interview in Dubai. “We have to decide by the end of October.”Sir Tim is having none of the media speculation and is looking further ahead.“I can never say never about ordering more A380s in the next decade. Much will depend on propulsion and on Airbus itself. With the orders we have we can see these aircraft fly to the late 2030s,” he says.The first A380s, delivered in 2008, will leave the Emirates fleet by late 2020 or early 2021, according to Clark.“The A380 is probably the biggest USP we have,” says Clark, with product upgrades coming in the pipeline: “We are trying to get our new First Class suites onto the A380 by 2021, while Premium Economy is coming already in 2020.”RUNWAY RENOVATION TO CUT FLIGHTSBefore that, he will have to ground almost half of his fleet during a 45-day renovation of the southern runway 12R-30L at Dubai International Airport which is due to take place from late April to early June 2019.Normally the airport handles over 1,100 movements a day, the runway closure cuts that down by 43 percent.READ: Emirates deal allows Dubai arrivals to get Uber and out.“I have to put 50 aircraft on the ground during runway renovation, all over the place,’’ he notes.“We might operate one or two A380s out of Dubai World Central in point-to-point traffic to deal with Easter demand, but otherwise it’s not ready, we can’t do that.”He expects a full move of Emirates’ operations to the yet-to-be fully built up new airport “by the late years of the next decade, in ten years plus from now.”In the meantime, the focus is on increasing efficiencies of the current terminals at Dubai International, which can’t be further extended.“That is where FlyDubai comes in,’’ he says. “When we start to integrate with them we will put some flights of FlyDubai in the southern terminals from November.”READ our ratings for EmiratesEmirates Uber deal discounted ridesDubai airport. Photo: Emirates.Emirates also has 250 people currently at using artificial intelligence to re-invent  IT processes and standards that Clark refers to as “Jurassic”.“AI allows us for example to become a lot better in aircraft stand planning for more efficiency and to bring unit costs down,” enthuses Clark.His “change agent” is his chief digital & innovation officer enterprise transformation Christoph Müller, the former CEO of Aer Lingus and Malaysia Airlines.Müller tells AirlineRatings that with his new tools it is possible to predict the exact minute an aircraft will appear at a gate twelve hours in advance, enabling better utilization.“This is about knocking everything down and rebuild it again, AI is going to make everything a better place,” Clark adds.ETIHAD SPECULATIONThe Emirates president, the last executive who has worked at Emirates since its foundation in 1985 besides chairman Sheikh Ahmed, vigorously denies on-going speculation about an imminent merger between his company with Abu Dhabi-based rival Etihad.“I don’t know where it came from,’’ he says. “I talk to Etihad CEO Tony Douglas a lot more than to his predecessor James Hogan about things that we could do together, which align and work together to deliver value together.“He is much more open and recognized they are in a bit of a hole and they have to do the things he is doing. And also (he) works with us, and not against us, in areas that we could.“We have been talking about sharing bits and pieces, but that’s as far as it got.“But then headlines like ‘Emirates is buying Etihad’ came out. I asked the Sheikh: ‘Is there something I should know?’. He said ‘No, I don’t know.’ This isn’t gonna happen, there is just nothing like that.”One of the reasons for that is regional politics.“You have to understand the politics of the region, the interactions, all the forces at play,’’ he says, noting a merger could be something that happened on paper but would not come about in practice.“Both Emirates respect competition and value brands. If you consolidate as one there is no competition.”He says the issue is ultimately one for the governments of Dubai and Abu Dhabi.“I’m just handling the business of the airline,’’ he says. “But I have no knowledge of this.”SUCCESSIONAnother issue seldom discussed by Sir Tim, a highly respected and powerful industry leader who turns 70 at the end of 2019, is his succession and when he might retire.In talking to AirlineRatings, he is fairly firm.“You’ve got to be able to mentally and physically lead a business,’’ he says. “Time will knock on the door and this is a younger man’s business.“And I say that even more now as change in the business is moving at such a pace. People say ‘that’s nuts that you are so involved’ and I say but that’s what I do.“My succession will be determined by the shareholder. When I choose to go that will be it.”He adds:  “It is very big shoes for anyone in this seat. It may be better that people are more transitory than I have been.”Sheikh Ahmed, the chairman, has stated publicly that he would like to see an Emirati take over the President’s job, rather than another expat.last_img read more

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SSL Certificates: What’s Left to Trust?

first_imgTuesday morning, Chicago-based authentication services provider Vasco Data Security announced its DigiNotar subsidiary, which issues certificates for SSL used to secure financial and other discrete transactions online, detected a security breach that forced it to issue improper certificates. One of those certificates, it admitted, was for Google.com.It would be a shocking occurrence if it weren’t so common. A root certificate authority (CA) is, by definition, the starting point for all trust in the Web transaction system. It self-signs its own certificate as a way of validating its own validity. Thus when DigiNotar’s validity isrevoked, as it was yesterday by Mozilla, among others, all the certificates it signs – including the one for itself – lose their authenticity.“The problem is much bigger than this one incident,” Sophos senior security researcher Chet Wisniewski tells RWW. “The whole idea that we ‘trust’ all of these entities shows that we have outgrown this model and the only safe thing to do for the moment is to remove them.”That may be safe, but so is staying locked up inside your house forever. Earlier this month, RWW’s David Strom suggested the introduction of “public notaries” for root certificates. Under such a system, users could choose the notaries they trust, and change that choice as conditions warrant. Tags:#Analysis#hack Some have argued that such a system is technically no different than what we have now: a series of largely unknown entities like DigiNotar that users never hear about until something goes wrong, and which they have no legitimate reason not to trust until then. Last April, after the authority incident to affect DigiNotar took place, security researcher Moxie Marlinspike wrote that the difference here lies in the user’s ability to distrust one entity and choose someone else instead – a difference that could introduce a modicum of competition.“It seems reasonable to think that we’ll need to anchor our trust somewhere. That we’ll pick some entity or group of entities to authenticate our communication. And right now, I could identify a set of organizations that I would trust to do this effectively. But what seems insane is to think that I could identify an organization who I would not only be willing to trust right now, but forever, without any future possibility of changing my mind based on that organization’s performance. If we’re locked into making a single decision now that will affect us forever, what incentive is there for the trust provider we select to act in a way that will continue to warrant our trust?”Marlinspike has devised his own working model of one of these notaries, called Convergence. He gave a briefing about the concept at the recent Black Hat security conference, shown in the video below.Wouldn’t the adoption of a notary system simply move the weakest link in the trust chain to a new location, and make that location the target of attack from whatever wants to call itself the Iranian revolutionary army?“The idea is somewhat complicated to explain. You remove CAs entirely from the process,” responds Wisniewski. “Then you pick a notary you trust (perhaps you run your own, you may choose to trust Moxie and the [Electronic Frontier Foundation] as well). When you surf to Gmail, you grab its cert. You also ask these notaries to grab Gmail’s cert. You then compare that the one you are getting matches these third parties. If they match, you know you are not being ‘man-in-the-middled.’ If you decide the EFF is no longer safe to not corroborate with your government to intercept and send you a fake cert, fine. Dump them and choose a different notary. Since there is no centralized authority that you must trust, you can choose and change your trust as you wish.”By “man-in-the-middled,” Wisniewski is referring to an attack process discovered last year by security researchers Christopher Sogohian and Sid Stamm (PDF available here.) The process takes advantage of the fact that some CAs will be receptive to requests from government authorities (which Wisniewski also referred to above) who wish to used forged certificates to convince suspects of their authenticity. Such CAs will often give these authorities fake certificates signed by them, which suspects’ browsers will then accept as legitimate.It then becomes a trivial matter for a malicious entity to effectively impersonate the government entity. What’s more, it isn’t necessary for that entity to spoof the CA that signs the real certificate, but rather any legitimate CA (which is why a DigiNotar signature can be accepted for a google.com certificate).Sogohian and Stamm wrote:“When compelling the assistance of a CA, the government agency can either require the CA to issue it a specific certificate for each website to be spoofed, or, more likely, the CA can be forced to issue an intermediate CA certificate that can then be re-used an infinite number of times by that government agency, without the knowledge or further assistance of the CA.“In one hypothetical example of this attack, the US National Security Agency (NSA) can compel VeriSign to produce a valid certificate for the Commercial Bank of Dubai (whose actual certificate is issued by Etisalat, UAE), that can be used to perform an effective man-in-the-middle attack against users of all modern browsers.”Perhaps more importantly, Sogohian and Stamm discovered, an actual industry was being formed around so-called turnkey intercept solutions that enable other agencies (or anyone, for the right price) to use this method automatically to compel fake certificates from CAs.“Placing trust in more than 600 certificate authorities to be honest and not screw up, is quite a leap of faith,” writes Sophos’ Wisniewski. “Be sure to enable certificate revocation checks in your browsers and take a close look at alternatives like Convergence.” scott fulton Related Posts How to Write a Welcome Email to New Employees? 7 Types of Video that will Make a Massive Impac… Why You Love Online Quizzes Growing Phone Scams: 5 Tips To Avoidlast_img read more

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Sony Attempts Attack To Prevent Access Of Stolen Data

first_imgTags:#cyber attacks#cybersecurity#DOS#malware#Sony lauren orsini A Web Developer’s New Best Friend is the AI Wai… Related Posts Sony is hacking back. See also: Latest Message From Sony Attackers Puts Suspicion On North KoreaWeeks after the company got its files compromised and four unreleased films leaked to the public, Sony is taking technological countermeasures to make those files difficult to access. The entertainment company is retaliating against locations sharing its leaked data, Recode reports. Amazon Web Services, a cloud computing service for businesses, operates data centers in Singapore and Tokyo. From there, Sony was using hundreds of computers in order to block the signal for locations hosting leaked Sony data, according to Recode’s anonymous sources. Amazon Web Services disagreed in a statement: “AWS employs a number of automated detection and mitigation techniques to prevent the misuse of our services. In cases where the misuse is not detected and stopped by the automated measures, we take manual action as soon as we become aware of any misuse. The activity being reported is not currently happening on AWS.” AWS did not specify whether the activity had occurred prior to now and was detected and stopped.See also: North Korea Praises But Won’t Take Credit For Sony HackSecurity researchers working with Sony have no idea who is behind the attacks, though a hacker group called “Guardians of Peace” has taken credit, and North Korea has pointedly praised the action, which leaked a film that was critical of leader Kim Jong-Un.However, Sony has tracked distributors of the file to locations in Asia, which is why the company is choosing to carry out its attacks from there. Update 1 p.m. ET: Article clarified to specify the attack type. Article updated with a statement from Amazon Web Services. Photo via Shutterstockcenter_img Why Tech Companies Need Simpler Terms of Servic… Top Reasons to Go With Managed WordPress Hosting 8 Best WordPress Hosting Solutions on the Marketlast_img read more

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How naked mole rats conquered pain—and what it could mean for us

first_imgAlthough it has a face—and body—that only a mother could love, the naked mole rat has a lot to offer biomedical science. It lives 10 times longer than a mouse, almost never gets cancer, and doesn’t feel pain from injury and inflammation. Now, researchers say they’ve figured out how the rodents keep this pain away.“It’s an amazing result,” says Harold Zakon, an evolutionary neurobiologist at the University of Texas, Austin, who was not involved with the work. “This study points us to important areas … that might be targeted to reduce this type of pain.”Naked mole rats are just plain weird. They live almost totally underground in colonies structured like honey bee hives, with hundreds of workers servicing a single queen and her few consorts. To survive, they dig kilometers of tunnels in search of large underground tubers for food. It’s such a tough life that—to conserve energy—this member of the rodent family gave up regulating its temperature, and they are able to thrive in a low-oxygen, high–carbon dioxide environment that would suffocate or be very painful to humans. “They might as well be from another planet,” says Thomas Park, a neuroscientist at the University of Illinois, Chicago.Sign up for our daily newsletterGet more great content like this delivered right to you!Country *AfghanistanAland IslandsAlbaniaAlgeriaAndorraAngolaAnguillaAntarcticaAntigua and BarbudaArgentinaArmeniaArubaAustraliaAustriaAzerbaijanBahamasBahrainBangladeshBarbadosBelarusBelgiumBelizeBeninBermudaBhutanBolivia, Plurinational State ofBonaire, Sint Eustatius and SabaBosnia and HerzegovinaBotswanaBouvet IslandBrazilBritish Indian Ocean TerritoryBrunei DarussalamBulgariaBurkina FasoBurundiCambodiaCameroonCanadaCape VerdeCayman IslandsCentral African RepublicChadChileChinaChristmas IslandCocos (Keeling) IslandsColombiaComorosCongoCongo, The Democratic Republic of theCook IslandsCosta RicaCote D’IvoireCroatiaCubaCuraçaoCyprusCzech RepublicDenmarkDjiboutiDominicaDominican RepublicEcuadorEgyptEl SalvadorEquatorial GuineaEritreaEstoniaEthiopiaFalkland Islands (Malvinas)Faroe IslandsFijiFinlandFranceFrench GuianaFrench PolynesiaFrench Southern TerritoriesGabonGambiaGeorgiaGermanyGhanaGibraltarGreeceGreenlandGrenadaGuadeloupeGuatemalaGuernseyGuineaGuinea-BissauGuyanaHaitiHeard Island and Mcdonald IslandsHoly See (Vatican City State)HondurasHong KongHungaryIcelandIndiaIndonesiaIran, Islamic Republic ofIraqIrelandIsle of ManIsraelItalyJamaicaJapanJerseyJordanKazakhstanKenyaKiribatiKorea, Democratic People’s Republic ofKorea, Republic ofKuwaitKyrgyzstanLao People’s Democratic RepublicLatviaLebanonLesothoLiberiaLibyan Arab JamahiriyaLiechtensteinLithuaniaLuxembourgMacaoMacedonia, The Former Yugoslav Republic ofMadagascarMalawiMalaysiaMaldivesMaliMaltaMartiniqueMauritaniaMauritiusMayotteMexicoMoldova, Republic ofMonacoMongoliaMontenegroMontserratMoroccoMozambiqueMyanmarNamibiaNauruNepalNetherlandsNew CaledoniaNew ZealandNicaraguaNigerNigeriaNiueNorfolk IslandNorwayOmanPakistanPalestinianPanamaPapua New GuineaParaguayPeruPhilippinesPitcairnPolandPortugalQatarReunionRomaniaRussian FederationRWANDASaint Barthélemy Saint Helena, Ascension and Tristan da CunhaSaint Kitts and NevisSaint LuciaSaint Martin (French part)Saint Pierre and MiquelonSaint Vincent and the GrenadinesSamoaSan MarinoSao Tome and PrincipeSaudi ArabiaSenegalSerbiaSeychellesSierra LeoneSingaporeSint Maarten (Dutch part)SlovakiaSloveniaSolomon IslandsSomaliaSouth AfricaSouth Georgia and the South Sandwich IslandsSouth SudanSpainSri LankaSudanSurinameSvalbard and Jan MayenSwazilandSwedenSwitzerlandSyrian Arab RepublicTaiwanTajikistanTanzania, United Republic ofThailandTimor-LesteTogoTokelauTongaTrinidad and TobagoTunisiaTurkeyTurkmenistanTurks and Caicos IslandsTuvaluUgandaUkraineUnited Arab EmiratesUnited KingdomUnited StatesUruguayUzbekistanVanuatuVenezuela, Bolivarian Republic ofVietnamVirgin Islands, BritishWallis and FutunaWestern SaharaYemenZambiaZimbabweI also wish to receive emails from AAAS/Science and Science advertisers, including information on products, services and special offers which may include but are not limited to news, careers information & upcoming events.Required fields are included by an asterisk(*)Gary Lewin, a neuroscientist at the Max Delbrück Center for Molecular Medicine in the Helmholtz Association in Berlin, began working with naked mole rats because a friend in Chicago was finding that the rodent’s pain fibers were not the same as other mammals’. In 2008, the studies led to the finding that naked mole rats didn’t feel pain when they came into contact with acid and didn’t get more sensitive to heat or touch when injured, like we and other mammals do. Lewin was hooked and has been raising the rodents in his lab ever since. They are a little more challenging than rats or mice, he notes, because with just one female per colony producing young, he never really has quite enough individuals for his studies.So instead of studying the whole animals, he began isolating single nerve cells from the mole rats and investigating them in lab dishes to track the molecular basis of the rodent’s pain insensitivity. The pain pathway is kicked off when a substance called nerve growth factor is released by injured or inflamed cells. This factor binds to a protein on the pain-cell surface, a so-called receptor named TrkA, which relays the “pain” message throughout the cell. In us and other mammals, that message increases the activity of a molecular pore, called the TRPV1 ion channel, causing the cell to become more sensitive to touch or heat. “So the cell says ‘It hurts more,’” Lewin explains.But that doesn’t happen in naked mole rats. Lewin evaluated the workings of the animal’s pain pathway components by mixing them with those of standard rats and putting the combinations in immature frog eggs. For example, the naked mole rat TRPV1 channel sensitized the egg to acid and heat when the rat TrkA was put into the egg cell with it. Thus, Lewin and his colleagues narrowed down the breakdown in this pathway to the TrkA receptor itself. The naked mole rat version of TrkA failed to activate the ion channel as efficiently as the rat version of TrkA, Lewin and his colleagues reveal today in Cell Reports.When they compared the amino acid sequence of naked mole rat protein, the researchers found that three of these protein building blocks were different from the rat version and one was also different from the same protein in other mole rats. That particular difference made the naked mole rat receptor inefficient at relaying the pain sensitization signal.Similar defects are seen in people, says Clifford Woolf, a neuroscientist at Boston Children’s Hospital and Harvard Medical School who was not involved with the work. But contrary to the portrayal of the unstoppable blond giant in The Girl Who Played with Fire, a mystery thriller by Swedish writer Stieg Larsson, “if an individual has mutations that reduce the capacity to feel pain, that’s extremely dangerous,” Woolf says. “It’s not a relief from pain; it’s a disaster,” because the body cannot detect when it’s hurt.But for naked mole rats, this drop of efficiency likely represents a good compromise, Lewin explains. Nerve growth factor and the receptor are important to the proper development of the nervous system. Thanks to this less efficient, albeit still functioning, receptor, the naked mole rat still winds up with an adequate nervous system, but with fewer pain nerve cells. That, in turn, could reduce the energy the animal needs to fuel its nervous system, likely useful in an environment where starvation is common and the body wants to conserve energy. “This illustrates how big steps in evolution can sometimes proceed from a single small mutation,” Zakon says.The naked mole rat work could inspire better pain treatments. “Traditional medical interventions for pain have frequently attempted a brute force approach, which can cause unintended bad side effects,” Park says. For example, neurologists have tried pain drugs that neutralize nerve growth factor and control pain without the use of opioids, say in arthritis. But sometimes the treatment leads to damage to the knee joint. “Using what has been learned from the Lewin paper,” it might be possible to tweak the receptor for nerve growth factor to limit this side effect, says Lorne Mendell, a neuroscientist at the State University of New York at Stony Brook.last_img read more

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Trisha Krishnan engaged to Varun Manian

first_imgTrisha, Varun pose for shutterbugs at their engagement ceremonyTamil actress Trisha Krishnan and entrepreneur-turned-producer Varun Manian exchanged rings at a private ceremony in Chennai amidst family and close friends.The engagement ceremony took place at Varun’s residence.For the ceremony, Trisha sported a specially customised sari by Neeta Lulla and jewellery by NAC jewellers, while Varun wore a simple white dhoti.Trisha, Varun at their engagement ceremony.The couple’s wedding date is yet to be finalised.Trisha and Varun have been dating for a few months since the former’s rumoured breakup with Telugu actor Rana Daggubati.Trisha, one of the top actresses in the south, made her Bollywood debut in 2010 opposite Akshay Kumar in Khatta Meetha directed by Priyadarshan.The actress insists she has no plans of quitting films after marriage and that instead, she plans on signing “two new films” soon.This year, Trisha awaits the release of her films Bhoologam, Yennai Arindhaal, RUM, Liona and Appa Takkaru.last_img read more

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